Mixed dose of Covishield and Covaccine creates better immunity against corona – ICMR study

New Delhi: The ICMR study has found that giving a mixed dose of Covishield and Covaccine, the two vaccines being given against corona in India, not only creates better immunity against corona, but it is also effective on the variants of corona. ICMR study print. 98 people were included in the study, out of which 40 people were given both doses of Covishield and 40 people were given both doses of Covaccine, and 18 people were given the first dose of Covishield and the second dose of Covaccine.

Under the National Corona Vaccination, 18 persons in Uttar Pradesh were either unknowingly or accidentally given the first dose of Kovishield Vaccine and the second dose of Covaccine. ICMR did an observational study to find out what happened to those who accidentally got these different vaccines, as well as to find out the safety and immunogenicity. In which they compared the safety and immunogenicity of those who received both doses of Covishield or Covaccine. 98 people were included in this observational study. Out of which 40 people were given both doses of Covishield and 40 people were given both doses of Covaccine, and there were 18 people who were given the first dose of Covishield and the second dose of Covaccine, in which 11 were men and 7 were women.

The findings of this observational study suggest that the inactivated whole virus vaccine was not only safer but also provided better immunogenicity after inoculation of the adenovirus vector platform-based vaccine. On the other hand, those who were given both the different doses showed significantly better immunogenicity profile against alpha, beta and delta variants of corona. Apart from this, antibodies and neutralizing antibodies were also very high.

Recently, the Subject Expert Committee of the Central Drug Standard Control Organization i.e. CDSCO has given permission to CMC, Vellore to conduct a mix clinical trial of both the vaccines used in corona vaccination in India, which will include 300 volunteers. To whom these two different vaccine doses will be given. So that it can be found out whether two different vaccine doses can be given to a person.

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